Dr. Sanchita Hati, Ph.D.

Sanchita Hati
  • Professor
  • Chemistry and Biochemistry
Teaching Interests
  • Biochemistry and Biophysical Chemistry   
Research and Creative Activities

My current research interests focus on the following two areas:

    • Enzymology: Experimental and computational studies of protein structure, dynamics, and function in intercellular-like environments  
    • Spectroscopy: Application of spectroscopic techniques in disease diagnosis and monitoring 
Education
  • Ph.D. in Chemistry, Indian Association for the Cultivation of Science, Jadavpur, India, 1997 
  • M.S. in Chemistry, University of Burdwan, India, 1991 
  • B.S. in Chemistry (Honors), Raj College, University of Burdwan, India, 1989 
Published Research

Recent Publications (‘*’ designates undergraduate students):

  • Fossum, C. J.*, Johnson, B. O. V. *, Golde, S. T. *, Kielman, A. J. *, Finke, B. *, Smith, M. A. *, Lowater, H. R. *, Laatsch, B. F. *, Bhattacharyya, S., and Hati, S. “Insight into the Mechanism of Tryptophan Fluorescence Quenching due to Synthetic Crowding Agents: A Combined Experimental and Computational Study” ACS Omega (2023) 8, 47, 44820–44830; https://doi.org/10.1021/acsomega.3c06006.
  • Laatsch, B. F. *, Brandt, M. *, Finke, B. *, Fossum, C. J. *, Wackett, M. J. *, Lowater, H. R. *, Narkiewicz-Jodko, A. *, Le, C. N. *, Yang, T., Glogowski, E. M., Bailey-Hartsel, S. C., Bhattacharyya, S., & Hati, S. "Polyethylene Glycol 20k. Does It Fluoresce?" ACS Omega (2023) 8, 14208–14218; https://doi.org/10.1021/acsomega.3c01124. 
  • Wozney, A. J.*, Smith, M. A.*, Abdrabbo, M.*, Birch, C. M.*, Cicigoi, K. A.*, Dolan, C. C.*, Gerzema, A. E. L.*, Hansen, A.*, Henseler, E. J.*, LaBerge, B.*, Leavens, C. M.*, Le, C. N.*, Lindquist, A. C.*, Ludwig, R. K.*, O'Reilly, M. G.*, Reynolds, J. H.*, Sherman, B. A.*, Sillman, H. W.*, Smith, M. A.*, Snortheim, M. J.*, Svaren, L. M.*, Vanderpas, E. C.*, Wackett, M. J.*, Wwiss, M. M.*, Hati, S. and Bhattacharyya, S., “Evolution of Stronger SARS-CoV-2 Variants as Revealed Through the Lens of Molecular Dynamics Simulations” Protein J. (2022) 41, 1-13; https://doi.org/10.1007/s10930-022-10065-6. 
  • Fossum, C. J.*, Laatsch, B. F.*, Lowater, H. R.* Narkiewicz-Jodko*, A. R.*, Lonzarich, L.*, Hati S. and Bhattacharyya, S. “Pre-existing Oxidative Stress Creates a Docking-Ready Conformation of the SARS-CoV-2 ReceptorBinding Domain” ACS Bio & Med Chem Au (2022) 2, 84–93; https://doi.org/10.1021/acsbiomedchemau.1c00040. 
  • Abdrabbo, M.*, Birch, C. M.*, Brandt, M., K. A.*, Coffey, S. J.*, Dolan, C. C.*, Dvorak, H.*, Gehrke, A. C.*, Gerzema, A. E. L.*, Hansen, A.*, Henseler, E. J.*, Huelsbeck, A. C.*, LaBerge, B.*, Leavens, C. M.*, Le, C. N.*, Lindquist, A. C.*, Ludwig, R. K.*, Reynolds, J. H.*, Severson, N. J.*, Sherman, B. A.*, Sillman, H. W.*, Smith, M. A.*, Smith, M. A.*, Snortheim, M. J.*, Svaren, L. M.*, Vanderpas, E. C.*, Wackett, M. J.*, Wozney, A. J.*, Bhattacharyya, S., and Hati, S. “Vitamin D and COVID-19: A Review on the Role of Vitamin D in Preventing and Reducing the Severity of COVID-19 Infection” Protein Science  (2021)30 , 2206-2220;  https://doi.org/10.1002/pro.4190.
  • Hu, Q. H.*; Williams, M. T.*; Shulgina, I.*; Fossum, C.*; Weeks, K.*; Adams, L.A.*; Reinhardt, C. R.*; Musier-Forsyth K.; Hati, S. †; and Bhattacharyya, S. “Editing Domain Motions Preorganize the Synthetic Active Site of Prolyl-tRNA Synthetase.” ACS Catal. (2020) 10, 10229-10242;  https://doi.org/10.1021/acscatal.0c02381.
  • Zajac, J.*; Anderson, H.*; Adams, L. A.*; Wangmo, D.*; Suhail, S.*; Almen, A.*; Berns, L.*; Coerber, B.*; Dawson, L.*; Hunger, A.*; Jehn, J.*; Johnson, J.*; Plack, N.*; Strasser, S.*; Williams, M. T.*; Bhattacharyya, S.; and Hati, S.  “Effects of Distal Mutations on Prolyl-adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase” Protein J. (2020) 39, 542-553;  https://doi.org/10.1007/s10930-020-09910-3. 
  • Suhail, S.*; Zajac, Z.*; Fossum, C.*; Lowater, H.*; McCracken, C.*; Severson, N.*; Laatsch, B.*; Narkiewicz-Jodko, A.*; Johnson, B.*; Liebau, J.*; Bhattacharyya, S.; and Hati, S.“Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review.” Protein J. (2020) 39, 644-656; https://doi.org/10.1007/s10930-020-09935-8.
  • Hati S. and Bhattacharyya, S. “Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin Converting Enzyme 2 Receptor.” ACS Omega (2020) 5, 16292-16298; https://doi.org/10.1021/acsomega.0c02125.   
  • Adams, L. A.*, Andrews, R. J.*, Hu, Q. H.*, Smit, H. L.*, Hati, S., and Bhattacharyya, S. “Crowder-Induced Conformational Ensemble Shift in Escherichia coli Prolyl-tRNA Synthetase.” Biophys. J. (2019) 117, 1269-1284; https://doi.org/10.1016/j.bpj.2019.08.033.
  • Reinhardt, C. R.*, Hu, Q. H.*, Bresnahan, C. G.*, Hati, S., Bhattacharyya, S. “Cyclic Changes in Active Site Polarization and Dynamics Drive the ‘Ping-pong’ Kinetics in NRH: Quinone Oxidoreductase 2: An Insight from QM/MM Simulations.” ACS Catal.(2018) 8, 12015–12029; https://doi.org/10.1021/acscatal.8b04193.
  • Hati S. and Bhattacharyya, S. “Integrating Research into the Curriculum – A Low-cost Strategy for Promoting Undergraduate Research”, ACS Book Chapter (Book: Best Practices for Supporting and Expanding Undergraduate Research in Chemistry) (2018) 119–141; https://pubs.acs.org/doi/abs/10.1021/bk-2018-1275.ch008. 
Honors and Recognitions
  • Career Excellence in Mentoring, Research, Scholarship, and Creative Activity Award, 2023, UW- Eau Claire
  • Faculty Excellence in Scholarship Award, 2021, UW- Eau Claire
  • University Merit Award, 2017, UW- Eau Claire
  • Recognized as High Demand Faculty, 2009, UW- Eau Claire
  • Lectureship and Research Fellowship Award in Chemistry, University Grant Commission, India
Professional Memberships
  • American Chemical Society