Authored by
DP
Title

Sanchita Hati, Ph.D.

Pronouns
she/her/hers
Placeholder for titles
Professor
Content type
College of Arts and Sciences
Chemistry and Biochemistry Department

Contact Information

Office
Phillips Hall 445
101 Roosevelt Avenue
Eau Claire, WI 54701
Phone
715-836-3850
Email
ID
Curriculum Vitae Google Scholar
Education

Education

  • Ph.D. in Chemistry, Indian Association for the Cultivation of Science, Jadavpur, India, 1997
  • M.S. in Chemistry, University of Burdwan, India, 1991
  • B.S. in Chemistry (Honors), Raj College, University of Burdwan, India, 1989 
Teaching and Research Interests

Teaching and Research Interests

  • Biochemistry and Biophysical Chemistry   

My current research interests focus on the following two areas:

  • Enzymology: Experimental and computational studies of protein structure, dynamics, and function in intercellular-like environments
  • Spectroscopy: Application of spectroscopic techniques in disease diagnosis and monitoring 
Published Research

Published Research

Selected publications from a total of 57 peer‑reviewed publications (‘*’ designates undergraduate students):

  1. Bhattacharyya, S. and Hati, S. "Fundamental Discoveries in Enzymology Through Undergraduate Research." ACS Omega (2025),10, 47831−47846; https://doi.org/10.1021/acsomega.5c07487.
  2. Gundry, S.*, Monsia, R.*, Mohr, M.*, Smith, M. A.*, Hati, S. and Bhattacharyya, S. "Graph Convolutional Neural Network-Enabled Frontier Molecular Orbital Prediction: A Case Study with Neurotransmitters and Antidepressants." J. Chem. Inf. Model. (2025) 65,7447−7462; https://doi.org/10.1021/acs.jcim.5c00724.
  3. Hati, S. and bhattacharyya, S. "Writing a Literature Review as a Class Project in an Upper-Level Undergraduate Biochemistry Course." S. Hati and S. Bhattacharyya. Biochem. Mol. Biol. Educ. (2024) 52, 311–316. https://doi.org/10.1002/bmb.21814.
  4. Fossum, C. J.*, Johnson, B. O. V. *, Golde, S. T. *, Kielman, A. J. *, Finke, B. *, Smith, M. A. *, Lowater, H. R. *, Laatsch, B. F. *, Bhattacharyya, S., and Hati, S. “Insight into the Mechanism of Tryptophan Fluorescence Quenching due to Synthetic Crowding Agents: A Combined Experimental and Computational Study”, ACS Omega (2023), 8, 47, 44820–44830; https://doi.org/10.1021/acsomega.3c06006
  5. Laatsch, B. F. *, Brandt, M. *, Finke, B. *, Fossum, C. J. *, Wackett, M. J. *, Lowater, H. R. *, Narkiewicz-Jodko, A. *, Le, C. N. *, Yang, T., Glogowski, E. M., Bailey-Hartsel, S. C., Bhattacharyya, S., & Hati, S. (2023). Polyethylene Glycol 20k. Does It Fluoresce? ACS Omega (2023) 8, 14208–14218; https://doi.org/10.1021/acsomega.3c01124.
  6. Wozney, A. J.*, Smith, M. A.*, Abdrabbo, M.*, Birch, C. M.*, Cicigoi, K. A.*, Dolan, C. C.*, Gerzema, A. E. L.*, Hansen, A.*, Henseler, E. J.*, LaBerge, B.*, Leavens, C. M.*, Le, C. N.*, Lindquist, A. C.*, Ludwig, R. K.*, O'Reilly, M. G.*, Reynolds, J. H.*, Sherman, B. A.*, Sillman, H. W.*, Smith, M. A.*, Snortheim, M. J.*, Svaren, L. M.*, Vanderpas, E. C.*, Wackett, M. J.*, Wwiss, M. M.*, Hati, S. and Bhattacharyya, S., “Evolution of Stronger SARS-CoV-2 Variants as Revealed Through the Lens of Molecular Dynamics Simulations”, Protein J. (2022) 41, 1-13; https://doi.org/10.1007/s10930-022-10065-6.
  7. Fossum, C. J.*, Laatsch, B. F.*, Lowater, H. R.* Narkiewicz-Jodko*, A. R.*, Lonzarich, L.*, Hati S. and Bhattacharyya, S. “Pre-existing Oxidative Stress Creates a Docking-Ready Conformation of the SARS-CoV-2 ReceptorBinding Domain”, ACS Bio & Med Chem Au (2022) 2, 84–93; https://doi.org/10.1021/acsbiomedchemau.1c00040.
  8. Abdrabbo, M.*, Birch, C. M.*, Brandt, M., K. A.*, Coffey, S. J.*, Dolan, C. C.*, Dvorak, H.*, Gehrke, A. C.*, Gerzema, A. E. L.*, Hansen, A.*, Henseler, E. J.*, Huelsbeck, A. C.*, LaBerge, B.*, Leavens, C. M.*, Le, C. N.*, Lindquist, A. C.*, Ludwig, R. K.*, Reynolds, J. H.*, Severson, N. J.*, Sherman, B. A.*, Sillman, H. W.*, Smith, M. A.*, Smith, M. A.*, Snortheim, M. J.*, Svaren, L. M.*, Vanderpas, E. C.*, Wackett, M. J.*, Wozney, A. J.*, Bhattacharyya, S., and Hati, S. “Vitamin D and COVID-19: A Review on the Role of Vitamin D in Preventing and Reducing the Severity of COVID-19 Infection”, Protein Science  (2021) 30 , 2206-2220; https://doi.org/10.1002/pro.4190.
  9. Hu, Q. H.*; Williams, M. T.*; Shulgina, I.*; Fossum, C.*; Weeks, K.*; Adams, L.A.*; Reinhardt, C. R.*; Musier-Forsyth K.; Hati, S. †; and Bhattacharyya, S.† “Editing Domain Motions Preorganize the Synthetic Active Site of Prolyl-tRNA Synthetase.” ACS Catal. (2020) 10, 10229-10242; https://doi.org/10.1021/acscatal.0c02381.
  10. Zajac, J.*; Anderson, H.*; Adams, L. A.*; Wangmo, D.*; Suhail, S.*; Almen, A.*; Berns, L.*; Coerber, B.*; Dawson, L.*; Hunger, A.*; Jehn, J.*; Johnson, J.*; Plack, N.*; Strasser, S.*; Williams, M. T.*; Bhattacharyya, S.; and Hati, S.† “Effects of Distal Mutations on Prolyl-adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase”, Protein J. (2020) 39, 542-553; https://doi.org/10.1007/s10930-020-09910-3.
  11. Suhail, S.*; Zajac, Z.*; Fossum, C.*; Lowater, H.*; McCracken, C.*; Severson, N.*; Laatsch, B.*; Narkiewicz-Jodko, A.*; Johnson, B.*; Liebau, J.*; Bhattacharyya, S.; and Hati, S.† “Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review.” Protein J. (2020) 39, 644-656; https://doi.org/10.1007/s10930-020-09935-8.
  12. Hati S. and Bhattacharyya, S.† “Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin Converting Enzyme 2 Receptor.” ACS Omega (2020) 5, 16292-16298; https://doi.org/10.1021/acsomega.0c02125. 
  13. Adams, L. A.*, Andrews, R. J.*, Hu, Q. H.*, Smit, H. L.*, Hati, S., and Bhattacharyya, S. “Crowder-Induced Conformational Ensemble Shift in Escherichia coli Prolyl-tRNA Synthetase.” Biophys. J. (2019) 117, 1269-1284; https://doi.org/10.1016/j.bpj.2019.08.033.
  14. Reinhardt, C. R.*, Hu, Q. H.*, Bresnahan, C. G.*, Hati, S., Bhattacharyya, S. “Cyclic Changes in Active Site Polarization and Dynamics Drive the ‘Ping-pong’ Kinetics in NRH: Quinone Oxidoreductase 2: An Insight from QM/MM Simulations.” ACS Catal. (2018) 8, 12015–12029; https://doi.org/10.1021/acscatal.8b04193.
  15. Hati S. and Bhattacharyya, S. “Integrating Research into the Curriculum – A Low-cost Strategy for Promoting Undergraduate Research”, ACS Book Chapter (Book: Best Practices for Supporting and Expanding Undergraduate Research in Chemistry) (2018) 119–141; https://pubs.acs.org/doi/abs/10.1021/bk-2018-1275.ch008.
Honors And Recognition

Honors And Recognition

  • CUR Chemistry Outstanding Mentorship Award, 2026
  • Career Excellence in Mentoring, Research, Scholarship, and Creative Activity Award, 2023, UW-Eau Claire
  • Faculty Excellence in Scholarship Award, 2021, UW-Eau Claire
  • University Merit Award, 2017, UW-Eau Claire
  • Recognized as High Demand Faculty, 2009, UW-Eau Claire
  • Lectureship and Research Fellowship Award in Chemistry, University Grant Commission, India