Print Header
Dedicated to Excellence



Phone: 715-836-2278


Ph.D. Indian Association for the Cultivation of Science, Jadavpur, India, 1997
M.S. Indian Institute of Technology, Kharagpur, India, 1991
B.S. Indian Institute of Technology, Kharagpur, India, 1989


Chem. 103, 115, and 104 General Chemistry

Chem. 213 Analytical Chemistry

Chem. 433 Physical Chemistry 1

Chem. 405 Applied Physical Chemistry

Chem. 497 Independent Study (ACS)


Computational and theoretical chemistry to probe the chemistry of enzymes

Redox Chemistry

Protein Dynamics

Selected Publications

(* denotes the UWEC undergraduate students)
Probing the Global and Local Dynamics of Aminoacyl-tRNA Synthetases using All-atom and Coarse-grained Simulations Strom, A.,* Fehling, S.*, Bhattacharyya, S., Hati, S. J. Mol. Mod. 2014, 20, 2245(1-11). View article online.

Strictly Conserved Lysine of Prolyl-tRNA Synthetase Editing Domain Facilitates Binding and Positioning of Misacylated tRNAPro
Bartholow, T. G.,* Sanford, B. L., Cao, B.V.,* Schmidt, H. L., Johnson, J. M., Meitzner, J. Bhattacharyya, S., Musier-Forsyth, K. M., Hati, S.Biochemistry 2014, 52, 1059-68. View article online

Comparison of the Intrinsic Dynamics of Aminoacyl-tRNA Synthetases
Warren, N.*,Strom, A.*, Nicolet, B.*, Albin, K.*, Albrecht, J.,* Bausch, B.* Dobbe, M.*, Dudek, M.*, Firgens, S.*, Fritsche, C.*, Gunderson, A.*, Heimann, J.*, Her, C.*, Hurt, J. * Konorev, D.*, Lively, M.*, Meacham, S.*, Rodriguez, V*, Tadayon, S.*, Trcka, D.*, Yang, Y.*, Bhattacharyya, S., and Hati, S.The Protein Journal 2014, 33,184-98. View article online

Multiple Pathways Promote Dynamical coupling between catalytic domains in escherichia coli prolyl-tRNA synthetase
Johnson, J. M.,* Sanford, B. L.,* Strom, A. S,* Tadayon, S.,* Brent, L.,* Zirbes, A.,* Bhattacharyya, S., Musier-Forsyth, K. M., Hati, S.Biochemistry 2013, 52, 4399-4412. View article online

Role of Coupled-dynamics in the Catalytic Activity of Prokaryotic-like Prolyl-tRNA Synthetases
Sanford, B.L., Cao, B.V.,* Johnson, J., Zimmerman, C., Strom, A. S.,* Mueller, R. M.,* Bhattacharyya, S., Musier-Forsyth, K. M., Hati, S. Biochemistry 2012, 51, 2146-2156. View article online

Interplay of flavin's redox states and protein dynamics: an insight from QM/MM simulations of dihydronicotinamide riboside quinone oxidoreductase 2
Mueller, R. M.,* North, M. A.,* Yang, C.,* Hati, S., Bhattacharyya, S. J. Phys. Chem. B 2011, 115, 3632-3641. View article online

Improved Density Functional Description of the Electrochemistry and Structure-property Descriptors of Substituted Flavins
North, M. A.,* Bhattacharyya, S., and Truhlar, D. G. J. Phys. Chem. B 2010, 114, 14907–14915. View article online

Theoretical Determination of the Redox Potentials of NRH:quinone oxidoreductase 2 using Quantum Mechanical/Molecular Mechanical Simulations
Rauschnot, J. C. Jr.,* Yang, C.,* Yang, V.,* and Bhattacharyya, S. J. Phys. Chem. B 2009, 113, 8149-8157. View article online

Evolutionary Basis for the Coupled-domain Motions in Thermus thermophilus Leucyl-tRNA Synthetase
Weimer, K. M. E.,* Shane, B. L., Brunetto, M., Bhattacharyya, S. and Hati, S. J. Biol. Chem. 2009, 284, 10088-99. View article online

Critical Role of Substrate Conformational Change in the Proton Transfer Process Catalyzed by 4-oxalocrotonate Tautomerase
Ruiz-Pernia, J. J.; Garcia-Viloca, M.;Bhattacharyya, S.; Gao, J.; Truhlar, D. G. and Tunon, I. J. Am. Chem. Soc.2009, 131, 2687-2698.