"Open Position, Modeling and Simulation Scientist in Preclinical Drug Development
16 Jan 2007
Who We Are
We are part of the Department of Pharmacokinetics (DMPK) at Roche Palo Alto, one of several global research sites of F. Hoffmann-La Roche based in Basel, Switzerland. Roche is recognized as a world leader among pharmaceutical companies. At Roche Palo Alto, we work on small molecules as well as biologics (therapeutic proteins).
Our Goals
The primary objective of the Preclinical Modeling & Simulation Group is to quantitatively predict the relationship between concentration and pharmacological effect (PK/PD) in humans based on preclinical data. This requires supporting drug discovery to identify new drug candidates by providing state of the art modeling and simulation predictions.
The Position
The successful candidate will be responsible for simulating toxicokinetic, human PK and pharmacokinetic / pharmacodynamic (PK/PD) relationships from preclincial data using state-of-the-art technologies. You will assist in study designs aimed at elucidating in vivo efficacy, elimination pathways and transporter interactions. You will be instrumental in dose selection for toxicological and first in man pharmacokinetic studies. Your responsibilities will include developing novel methods to address modeling and simulation issues. Presentation and publication of research findings is encouraged.
Who You Are
You are a self-starter and have an M.S. or PhD (or equivalent) in pharmaceutical or biomedical science with experience in mathematical modeling preferably in preclinical or clinical pharmacokinetics and/or pharmacology. You like to work on multiple projects in parallel and in a fast paced and rewarding environment. You are an excellent presenter and communicator. You are an experienced pharmacokineticist and have formal training in pharmacology, biology, and toxicology. You have used PBPK, PK/PD, and classical PK models and are proficient with WinNonlin. Experience with IVIVC/IVIVE analysis, population PK methods, GastroPlus, and QSAR or QPPR modeling is a plus.
Who to Contact
For more information, please contact Dr. Carl Brown at 650-855-5621 (email: carl.brown@roche.com) or Dr. Micaela Reddy at 650-855-5239 (email: micaela.reddy@roche.com)."
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Modeling and Simulation of Drugs - Palo Alto, CA
Posted - 01/17/2007 : 15:54:18
