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Outlook 2007 provides you with a feature to automatically reply to emails sent to you while you are away. The Out of Office Assistant will send a specified message to each sender. The message helps senders understand why you are unavailable, who to contact in your place, how else to contact you, or other information. Out of Office messages will be sent only once per sender, no matter how many times they send a message to you.
WARNING: If you receive a junk message with Out of Office replies turned on, you may reply to that junk message. Doing so may validate your email address to the sender, inadvertently adding you to the junk sender's recipient list. You can avoid this by setting Out of Office messages to send to your Contacts only. For more information, refer to Creating Out of Office Replies. Updating your junk email filters will be helpful too. For more information, refer to Using Junk Email Filters.
The following are some things to consider when creating Out of Office replies.
Some messages may be urgent. Include the names and addresses of alternate contacts in your stead. If you are going to be gone for an extended absence (e.g., sabbatical), consider including multiple contacts.
Explain when you will be available again.
If you are subscribing to any discussion lists (listservs), sign off or suspend your subscription to prevent your Out of Office message from going to all of the list members.
If appropriate, include the reason why you are unavailable.
Consider the creation of Out of Office messages a part of your preparations for your absence. Outlook allows you to create two different Out of Office messages: one which will reply to messages sent from from your organization, and one which will reply to messages sent from anyone not from your organization, or if specified, your Contacts list.
NOTE: Once you have applied the Out of Office Assistant, a a pop-up bubble will appear the next time you open Outlook, notifying you that it is turned on.
From the Tools menu, select Out of Office Assistant...
The Out of Office Assistant appears.

Select Send Out of Office auto-replies
From the Start time and End time pull-down lists, select the desired date and time range
In the text box, type your desired message
In the text box, type the desired message
Click OK
The Out of Office Assistant closes and Out of Office messages are applied.
When you return from an absence, you will want to promptly turn off Out of Office replies.
If the Out of Office Assistant is on, when you open Outlook, a pop-up bubble will appear to notify you that it is still activated. You can turn off Out of Office replies with this pop-up bubble.
Open Outlook
Outlook loads and a pop-up bubble appears in the lower right corner, indicating that Out of Office replies are still activated.
Click the pop-up bubble
NOTE: The pop-up bubble will disappear if no action is taken. If this occurs, refer to Turning Off Out of Office Replies: Outlook Already Open.
The Out of Office Assistant appears.
Select Do not send Out of Office auto-replies
Click OK
The Out of Office Assistant closes.
At the bottom of the Outlook window, click OUT OF OFFICE
» select Turn off Out of Office auto-replies
All Out of Office replies are turned off.