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Dedicated to Excellence

ASSOCIATE PROFESSOR

Chemistry

Phone: 715-836-3850
Email: hatis@uwec.edu

Education

Ph.D. Indian Association for the Cultivation of Science, Jadavpur, India, 1997

M.S. University of Burdwan, India, 1991

B.S. Raj College, University of Burdwan, India, 1989


Courses

Chem. 103 General Chemistry
Chem. 406 Biophysical Chemistry
Chem. 452 Biochemistry I
Chem. 453 Biochemistry laboratory I
Chem. 454 Biochemistry II
Chem. 455 Biochemistry laboratory II
Chem. 497 Independent Study (ACS)


Research

Protein Dynamics and Catalysis

RNA Catalysis


Selected Publications

Multiple pathways promote dynamical coupling between catalytic domains in Escherichia coli prolyl-tRNA synthetase. J. M. Johnson, B. L. Sanford, A. M. Strom, S. N. Tadayon, B. P. Lehman, A. M. Zirbes, S. Bhattacharyya, K. Musier-Forsyth, and S. Hati (2013) Biochemistry, 52, 4399-4412.

Role of coupled motions in the catalytic activity of prokaryotic-like prolyl-tRNA synthetases. B. L. Sanford, B. V. Cao, J. M. Johnson, K. Zimmerman, A. M. Storm, R. M. Mueller, S. Bhattacharyya, K. Musier-Forsyth, and S. Hati (2012) Biochemistry, 51, 2146-2156.

Interplay of flavin's redox states and protein dynamics: an insight from QM/MM simulations of dihydronicotinamide riboside quinone oxidoreductase 2. R. M. Mueller, M. A. North, C. Yang, S. Hati, and S. Bhattacharyya (2011) J. Phys. Chem. B, 115, 3632-3641.

Evolutionary basis for the coupled-domain motions in Thermus thermophilus leucyl-tRNA synthetase. K. M. Weimer, B. L. Shane, M. Brunetto, S. Bhattacharyya, and S. Hati (2009) J. Biol. Chem., 284, 10088-10099.

Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain.J. SternJohn, S. Hati, P. G. Siliciano, and K. Musier-Forsyth (2007) Proc. Natl. Acad. Sci. USA, 104, 2127-32.

Pre-transfer editing by class II prolyl-tRNA synthetase: role of aminoacylation active site in "selective release" of noncognate amino acids. S. Hati, B. Ziervogel, J. SternJohn, F. C. Wong, M. C. Nagan, A. R. Rosen, P. G. Siliciano, J. Chihade, and K. Musier-Forsyth (2006) J. Biol. Chem., 281, 27862-27872.

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